Brand Name: TEXONE®
Generic name: Ceftriaxone
TEXONE® is the “third generation of cephalosporins” and “antibiotics”.
It is used in the treatment of susceptible bacterial infections, including cannabis, endocarditis, salmonellosis, shigellosis, gonorrhea, meningitis, meningitis, meningitis, septicemia and typhoid.
TEXONE® also used before the surgery to prevent infection.
The mechanism of Action:
Like other antibiotics, this drug prevents the formation of cell walls in bacteria. The cell wall in bacteria protects cells against environmental factors and if the wall does not form completely, the bacteria will burst into the water by water absorption. The TEXONE® replaces the peptidoglycan constituents in the final stage of the formation of peptidoglycans and causes the formation of a defective cell wall.
TEXONE® follows a dose-dependent nonlinear kinetics due to protein binding. The peak concentration of the drug is obtained after intramuscular injection for up to 2 hours. The half-life of the drug is 9-6 hours. It is widely distributed in body tissues and fluids. More than half of the dose of the drug is excreted in the urine and unchanged and the rest is excreted through the feces in the form of unchanged and inactive compounds.
If there is a history of excessive sensitivity to penicillins, cephalosporins or penicillamine, porphyria, and in infants with little blood albumin, acidosis, jaundice, or excessive bilirubin, it is not recommended.
- If you have a history of gastrointestinal disease, take this medicine with caution.
- In patients with liver or kidney damage, it is necessary to reduce the amount of this drug.
- In premature infants, this drug may cause bilirubin to be converted from serum albumin.
- Infusion of this drug in newborns should be done slowly and within 60 minutes.
Side effects of this medication include chest pain, chills, coughing, fever, shortness of breath, painful or difficult urine, sore throat, swelling of the glands, fatigue or abnormal weakness.
If cephalosporins are co-administered with aminoglycosides and vancomycin, the risk of renal toxicity increases.
The use of TEXONE® with serum ringer and other calcium-containing compounds (such as calcium gluconate ampoule) can be fatal.
Mixing this drug with other drugs, especially aminoglycosides, is not recommended in one solution.
Adults: 1 to 2grams of medicines are given by intramuscular or intravenous infusion once a day or in separate doses twice a day. The maximum daily dose of TEXONE® is 4grams.
Childs: The total daily dose is 50 to 75mg per kg body weight per child and it is used in two divided doses every 12 hours.
This medicine is available in vials at doses of 2g, 1g, 500mg and 250mg.
TEXONE® drug with a dose of 1 g of vial is available in the pharmaceutical basket of Pars Pharmed Company. Providing all documents related to the manufacture and analysis of this product to the Food and Drug Agency, the license and the export license was issued.