Brand Name: MEROVIAL®

Generic name: Meropenem

Pharmaceutical category:
MEROVIAL® injection is in a class of medications called antibiotics. It works by killing bacteria that cause infection.

Uses of:
MEROVIAL® injection is used to treat skin and abdominal (stomach area) infections caused by bacteria and meningitis (infection of the membranes that surround the brain and spinal cord) in adults and children 3 months of age and older.The spectrum of action includes many Gram-positive and Gram-negative bacteria (including Pseudomonas) and anaerobic bacteria. The overall spectrum is similar to that of imipenem, although MEROVIAL® is more active against Enterobacteriaceae and less active against Gram-positive bacteria. It works against extended-spectrum β-lactamases, but may be more susceptible to metallo-β-lactamases. MEROVIAL® is frequently given in the treatment of febrile neutropenia. This condition frequently occurs in patients with hematological malignancies and cancer patients receiving anticancer drugs that suppress bone marrow formation. It is approved for complicated skin and skin structure infections, complicated intra-abdominal infections and bacterial meningitis.
In 2017 the FDA granted approval for the combination of Meropenem and vaborbactam to treat adults with complicated urinary tract infections.

Mechanism of action:
The bactericidal activity of MEROVIAL® results from the inhibition of cell wall synthesis. MEROVIAL® readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding- protein (PBP) targets. Its strongest affinities are toward PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa; and PBPs 1, 2 and 4 of Staphylococcus aureus.

– Clostridium difficile infection
– Decreased blood platelets
– Lesion of the brain
– Seizures
– Chronic kidney disease stage 4 (severe)
– Chronic kidney disease stage 5 (failure)
– Kidney disease with likely reduction in kidney function
– Betalactams
– Carbapenems

Drug Interactions:
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Side effects:
The most common adverse effects are diarrhea (4.8%), nausea and vomiting (3.6%), injection-site inflammation (2.4%), headache (2.3%), rash (1.9%) and thrombophlebitis (0.9%). Many of these adverse effects were observed in severely ill individuals already taking many medications including vancomycin. MEROVIAL® has a reduced potential for seizures in comparison with imipenem. Several cases of severe hypokalemia have been reported. MEROVIAL®, like other carbapenems, is a potent inducer of multidrug resistance in bacteria.

Dosage Forms & Strengths:
Powder for injectable solution

MEROVIAL® in the dosage of 500/1000mg in the pharmaceutical basket of Pars pharmed company can be presented to the market. Providing all documents related to the manufacture and analysis of this product to the Food and Drug Agency, the license and the export license was issued.